Regulatory T cells (Tregs) play a critical role in maintaining self-tolerance and in containing
allo-immune responses in the context of transplantation. Recent advances yielded the …

Novel biologics are currently being tested in clinical trials for the treatment of autoimmune
diseases and the prevention of transplant allograft rejection. Their premise is to deliver …

Long-term organ transplant survival remains suboptimal, and life-long immunosuppression
predisposes transplant recipients to an increased risk of infection, malignancy, and kidney …

The efficacy of costimulation blockade with CTLA4-Ig (belatacept) in transplantation is
limited due to T cell-mediated rejection, which also persists after induction with anti …

The immune system plays a vital role in maintaining tissue integrity and organismal
homeostasis. The sudden stress caused by myocardial infarction (MI) poses a significant …

Simple Summary The immune system spontaneously recognizes and destroys foreign cells
and organs when grafted into a genetically different individual. Organ transplantation is only …

The scintillating association between Leishmania and HIV has contributed exceptionally
towards expansion of Visceral Leishmaniasis (VL) with Acquired Immunodeficiency …

Induction of major histocompatibility complex (MHC) human leukocyte antigen (HLA)-
mismatched mixed chimerism is a promising approach for organ transplantation tolerance; …

Post‐transplantation immune rejection remains an important factor for transplant patients.
However, conventional immunosuppressants are associated with substantial adverse …

Background: Antithymocyte globulins (ATG) are T cell-depleting antibodies used in solid
organ transplantation for induction therapy in sensitized patients with a high risk of graft …