Hyperprogressive disease (HPD) is a recently acknowledged pattern of rapid tumor
progression after the initiation of immune checkpoint inhibitors. HPD has been observed …

Uveal melanoma (UM) represents the most common intraocular malignancy in adults and
accounts for about 5% of all melanomas. Primary disease can be effectively controlled by …

Liver metastasis is highly aggressive and treatment-refractory, partly due to macrophage-
mediated immune suppression. Understanding the mechanisms leading to functional …

Background Patients with metastatic melanoma have variable responses to combination
ipilimumab and nivolumab. The objectives of this study were to examine the patterns of …

Resistance remains an obstacle to anti-programmed cell death protein 1 (PD-1) therapy in
human cancer. One critical resistance mechanism is the lack of T cell chemotaxis in the …

Activated hepatic stellate cell (aHSC)-mediated liver fibrosis is essential to the development
of liver metastasis. Here, we discover intra-hepatic scale-up of relaxin (RLN, an anti-fibrotic …

Background Predictive factors of nivolumab treatment response in patients with gastric
cancer (GC) remain unclear. Methods In this retrospective cohort study, tissue specimens of …

Oligoprogression (OPD) of non-small-cell lung cancer (NSCLC) occurs in approximately half
of patients under targeted compounds (TKI) and facilitates use of regional therapies that can …

Purpose To conduct a retrospective multicenter trial to determine the significance of
metastatic site as a predictor of nivolumab efficacy in patients with advanced non-small cell …

Background: Mucosal and acral melanoma respond worse to immune checkpoint inhibitors
(ICI) than cutaneous melanoma. MDM2/4 as well as EGFR amplifications are supposed to …