ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease

DSA Simpson, PL Oliver - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …

Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances

W Wang, F Zhao, X Ma, G Perry, X Zhu - Molecular neurodegeneration, 2020 - Springer
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Somatic genomic changes in single Alzheimer's disease neurons

MB Miller, AY Huang, J Kim, Z Zhou, SL Kirkham… - Nature, 2022 - nature.com
Dementia in Alzheimer's disease progresses alongside neurodegeneration,,–, but the
specific events that cause neuronal dysfunction and death remain poorly understood. During …

Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases

F Collin - International journal of molecular sciences, 2019 - mdpi.com
Increasing numbers of individuals suffer from neurodegenerative diseases, which are
characterized by progressive loss of neurons. Oxidative stress, in particular, the …

Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

[HTML][HTML] Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C Cheignon, M Tomas, D Bonnefont-Rousselot… - Redox biology, 2018 - Elsevier
Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …

Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view

G Cenini, A Lloret, R Cascella - Oxidative medicine and …, 2019 - Wiley Online Library
Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

Oxidative stress and aging as risk factors for Alzheimer's disease and Parkinson's disease: the role of the antioxidant melatonin

J Tchekalarova, R Tzoneva - International journal of molecular sciences, 2023 - mdpi.com
Aging and neurodegenerative diseases share common hallmarks, including mitochondrial
dysfunction and protein aggregation. Moreover, one of the major issues of the demographic …

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Oxidative stress in alzheimer's disease: A review on emergent natural polyphenolic therapeutics

L Cassidy, F Fernandez, JB Johnson, M Naiker… - … therapies in medicine, 2020 - Elsevier
Objectives The aim of this research was to review the literature on Alzheimer's disease (AD)
with a focus on polyphenolics as antioxidant therapeutics. Design This review included a …