Neurocognitive problems have been endemic to the HIV epidemic since its beginning. Four
decades later, these problems persist, but currently, they are attributed to HIV-induced …

With the advent and widespread use of antiretroviral therapy (ART), the epidemiology of
cardiomyopathy and heart failure (HF) associated with HIV infection is changing. Near …

The JAK-STAT pathway is activated in both macrophages and lymphocytes upon human
immunodeficiency virus type 1 (HIV-1) infection and thus represents an attractive cellular …

Objectives Chronic hepatitis C virus (HCV) and HIV viral infections are characterized by
systemic inflammation. Yet the relative levels, drivers and correlates of inflammation in these …

Objective: Microbial translocation has been suggested to be a driver of immune activation
and inflammation. It is hypothesized that microbial translocation may be related to …

Objective: The objective of this study is to assess whether multivariate normative comparison
(MNC) improves detection of HIV-1-associated neurocognitive disorder (HAND) as …

Objective Chronic inflammation and vascular dysfunction (eg, chronic endothelial activation)
are related yet dissociable mechanisms of HIV-associated neurocognitive impairment (NCI) …

Background Systemic inflammation is a characteristic of both HIV-1 infection and aging
(“inflammaging”). Intestinal epithelial barrier damage (IEBD) and microbial translocation …

Many sets of data indicate that HIV-infected individuals maintain a low level of chronic
immune activation and inflammation even in the presence of effective antiretroviral therapy …

Background Diastolic dysfunction (DD) is common and occurs at an earlier age among
human immunodeficiency virus-infected (HIV+) individuals, but the mechanisms and …