[HTML][HTML] Oxidative stress in malaria
S Percário, DR Moreira, BAQ Gomes… - International journal of …, 2012 - mdpi.com
Malaria is a significant public health problem in more than 100 countries and causes an
estimated 200 million new infections every year. Despite the significant effort to eradicate …
estimated 200 million new infections every year. Despite the significant effort to eradicate …
Synthetic methodologies of achiral diarylmethanols, diaryl and triarylmethanes (TRAMs) and medicinal properties of diaryl and triarylmethanes-an overview
The last decade has witnessed a high demand of various synthetic approaches towards
bioactive achiral diarylmethanols, diaryl and triarylmethanes and the molecules derived …
bioactive achiral diarylmethanols, diaryl and triarylmethanes and the molecules derived …
Antimalarial activity of small-molecule benzothiazole hydrazones
We synthesized a new series of conjugated hydrazones that were found to be active against
malaria parasite in vitro, as well as in vivo in a murine model. These hydrazones …
malaria parasite in vitro, as well as in vivo in a murine model. These hydrazones …
[HTML][HTML] Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities …
Macrophage migration inhibitory factor (MIF) is responsible for proinflammatory reactions in
various infectious and non-infectious diseases. We have investigated the mechanism of anti …
various infectious and non-infectious diseases. We have investigated the mechanism of anti …
Redox-active antiparasitic drugs
C Pal, U Bandyopadhyay - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: Parasitic diseases affect hundreds of millions of people worldwide and
represent major health problems. Treatment is becoming extremely difficult due to the …
represent major health problems. Treatment is becoming extremely difficult due to the …
Reactivity vs. selectivity of quinone methides: synthesis of pharmaceutically important molecules, toxicity and biological applications
Quinone methides (QMs) are considered to be highly reactive intermediates because of their
aromatization both in chemical and biological systems. Being highly accessible, quinone …
aromatization both in chemical and biological systems. Being highly accessible, quinone …
[HTML][HTML] Elucidation of potential anticancer, antioxidant and antimicrobial properties of some new triazole compounds bearing pyridine-4-yl moiety and cyclobutane …
Abstract Thiosemicarbazides (2a–e) were obtained by the interaction of pyridine-4-
carboxylic acid hydrazide (1) with five different isothiocyanate (RNCS) derivatives. By …
carboxylic acid hydrazide (1) with five different isothiocyanate (RNCS) derivatives. By …
Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis
Activation of the mitochondrial apoptosis pathway by oxidative stress has been implicated in
hepatocyte apoptosis during malaria. Because mitochondria are the source and target of …
hepatocyte apoptosis during malaria. Because mitochondria are the source and target of …
Antimalarial Activity of Highly Coordinative Fused Heterocycles Targeting β-Hematin Crystallization
ME Acosta, L Gotopo, N Gamboa, JR Rodrigues… - ACS …, 2022 - ACS Publications
The β-hematin formation is a unique process adopted by Plasmodium sp. to detoxify free
heme and represents a validated target to design new effective antimalarials. Most of the β …
heme and represents a validated target to design new effective antimalarials. Most of the β …
Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum
We have investigated the DNA-binding nature as well as the function of a putative Alba
(Acetylation lowers binding affinity) family protein (PfAlba3) from Plasmodium falciparum …
(Acetylation lowers binding affinity) family protein (PfAlba3) from Plasmodium falciparum …