Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …

Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses
against environmental stresses. NRF2 induces expression of detoxification and antioxidant …

Environmental pollution is one of the most serious challenges to health in the modern world.
Pollutants alter immune responses and can provoke immunotoxicity. In this Review, we …

The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the
master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective …

Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis …

Simple Summary Nuclear factor erythroid-derived 2-like 2 (encoded by the Nfe2l2 gene;
NRF2) is a transcription factor that regulates a variety of cytoprotective genes, including …

Abstract The Keap1-Nrf2 system is central for mammalian cytoprotection against various
stresses and a drug target for disease prevention and treatment. One model for the …

Activation of the transcription factor Nrf2 via the Keap1–Nrf2–ARE signaling system
regulates the transcription and subsequent expression of cellular cytoprotective proteins and …

In a multicellular environment, many different types of cells interact with each other. The
KEAP1–NRF2 system defends against electrophilic and oxidative stresses in various types …