FLT3-ITD and FLT3-TKD mutations were observed in approximately 20 and 10% of acute
myeloid leukemia (AML) cases, respectively. FLT3 inhibitors such as midostaurin, gilteritinib …

Multiple studies have demonstrated that interaction with the bone marrow stromal
microenvironment contributes to the survival of leukemia cells. One explanation for this …

Extrinsic signaling cues in the microenvironment of acute myelogenous leukemia (AML)
contribute to disease progression and therapy resistance. Yet, it remains unknown how the …

Drug resistance is a growing area of concern. It has been shown that a small, residual pool
of leukemic CD34+ progenitor cells can survive in the marrow microenvironment of chronic …

Acute myeloid leukemia (AML) is a bone marrow malignancy, and various bone marrow
stromal cells seem to support leukemogenesis, including osteoblasts and endothelial cells …

Cure rates in pediatric acute leukemias remain suboptimal. Overexpression of the cell-
surface chemokine receptor CXCR4 is associated with poor outcome in acute lymphoblastic …

Acute myeloid leukemia (AML) is the result of a multistep transforming process of
hematopoietic precursor cells (HPCs) which enables them to proceed through limitless …

The presence of FLT3 mutations, including the most common FLT3-ITD (internal tandem
duplications) and FLT3-TKD (tyrosine kinase domain), is associated with an unfavorable …

CXCR4 is expressed on leukaemia cells and haematopoietic stem cells (HSCs), and its
ligand stromal‐derived factor 1 (SDF‐1) is produced abundantly by stromal cells in the bone …

With the tremendous increase of publicly available single-cell RNA-sequencing (scRNA-
seq) datasets, bioinformatics methods based on gene co-expression network are becoming …