Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a
requisite role in the maintenance of immunological homeostasis and prevention of …

Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

The HLH-2004 criteria are used to diagnose hemophagocytic lymphohistiocytosis (HLH), yet
concern exists for their misapplication, resulting in suboptimal treatment of some patients …

Background & aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the
essential roles of individual genes in pathways and networks safeguarding immune …

Human NK cells are innate immune effectors that play a critical roles in the control of viral
infection and malignancy. The importance of their homeostasis and function can be …

Disclosures: J. Raedler reported grants from Foerderprogramm fuer Forschung und Lehre
(FöFoLe), Medical Faculty, LMU Munich, Germany outside the submitted work. A. Fasth …

Infections with any of the nine human herpes viruses (HHV) can be asymptomatic or life-
threatening. The study of patients with severe diseases caused by HHVs, in the absence of …

Giant condyloma acuminatum, also known as Buschke-Lowenstein tumor (BLT), is a rare
disease of the anogenital region. BLT is considered a locally aggressive tumor of benign …

The actin cytoskeleton is composed of dynamic filament networks that build adaptable local
architectures to sustain nearly all cellular activities in response to a myriad of stimuli …

Background Biallelic loss‐of‐function mutations in CARMIL2 cause combined
immunodeficiency associated with dermatitis, inflammatory bowel disease (IBD), and EBV …