Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …

There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Inherited Cardiomyopathies | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

Purpose Genetic testing has advanced significantly since the publication of the 2011
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the …

Rationale: The transverse tubule (T-tubule) system is the ultrastructural substrate for
excitation–contraction coupling in ventricular myocytes; T-tubule disorganization and loss …

Over the last 2 decades, the pathogenic basis for the most common heritable cardiovascular
disease, hypertrophic cardiomyopathy (HCM), has been investigated extensively. Affecting …

Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …

Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous cardiac muscle
disorder with a diverse natural history, characterized by unexplained left ventricular …

Hypertrophic cardiomyopathy (HCM) is the most-common monogenically inherited form of
heart disease, characterized by thickening of the left ventricular wall, contractile dysfunction …