Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research

OPS Patel, RM Beteck, LJ Legoabe - European journal of medicinal …, 2021 - Elsevier
Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …

An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins

H Madhav, N Hoda - European Journal of Medicinal Chemistry, 2021 - Elsevier
Malaria is an endemic disease, prevalent in tropical and subtropical regions which cost half
of million deaths annually. The eradication of malaria is one of the global health priority …

Chemoenzymatic synthesis of 13-oxoverruculogen

J Yang, B Singh, G Cohen, CP Ting - Journal of the American …, 2023 - ACS Publications
Verruculogens are rare fumitremorgin alkaloids that contain a highly unusual eight-
membered endoperoxide. In this paper, we report a concise chemoenzymatic synthesis of …

Allylative Approaches to the Synthesis of Complex Guaianolide Sesquiterpenes from Apiaceae and Asteraceae

X Hu, AJ Musacchio, X Shen, Y Tao… - Journal of the American …, 2019 - ACS Publications
With hundreds of unique members isolated to date, guaianolide lactones represent a
particularly prolific class of terpene natural products. Given their extensive documented …

Evolution of a synthetic strategy for complex polypyrrole alkaloids: total syntheses of curvulamine and curindolizine

J Xuan, KT Haelsig, M Sheremet… - Journal of the …, 2021 - ACS Publications
Structurally unprecedented antibacterial alkaloids containing multiple electron-rich pyrrole
units have recently been isolated from Curvularia sp. and Bipolaris maydis fungi. This article …

[PDF][PDF] Optimization of Total Flavonoid Content from Cardamom Fruits Using a Simplex-Centroid Design, Along with the Evaluation of the Antioxidant Properties: doi …

W Nurcholis, K Ma'rifah, MI Artika… - Tropical Journal of …, 2021 - researchgate.net
The fruits of Cardamom (Amomum compactum Sol. Ex Maton; Zingiberaceae), commonly
known as Queen species, which contained flavonoid compounds, have a variety of …

Forest Fevers: traditional treatment of malaria in the southern lowlands of Laos

E Elliott, F Chassagne, A Aubouy, E Deharo… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Malaria is still a highly challenging public health issue in
southern Lao PDR, with increasing cases of artemisinin resistance and Plasmodium vivax …

Syntheses of complex terpenes from simple polyprenyl precursors

CS Harmange Magnani, DQ Thach… - Accounts of chemical …, 2020 - ACS Publications
Conspectus From structure elucidation and biogenesis to synthetic methodology and total
synthesis, terpene natural products have profoundly influenced the development of organic …

Enzymatic Peroxidation in the Chemoenzymatic Synthesis of 13-Oxoverruculogen

B Singh, CP Ting - Synlett, 2025 - thieme-connect.com
Verruculogens are fumitremorgin alkaloids that contain an eight-membered endoperoxide
ring. Due to their unusual structure and bioactivity, there has been much interest in these …

ANALYSIS OF PLANT INGREDIENTS IN REMEDIAL FORMULATIONS OF MALARIA IN MALAY MEDICAL MANUSCRIPTS

HKJ TAMKIN, IA NADZIRIN - INTERNATIONAL JOURNAL OF …, 2023 - journals.iium.edu.my
Introduction: Malaria is an infectious disease caused by Plasmodium spp. The main
treatment is artemisinin which was discovered after a massive study on Chinese medical …