Thirty years after the discovery of its production by activated macrophages, our appreciation
of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only …

Over the last decade, a dual character of cell response to oxidative stress, eustress versus
distress, has become increasingly recognized. A growing body of evidence indicates that …

Significance: Protein S-nitrosylation, the oxidative modification of cysteine by nitric oxide
(NO) to form protein S-nitrosothiols (SNOs), mediates redox-based signaling that conveys, in …

NO is a versatile free radical that mediates numerous biological functions within every major
organ system. A molecular pathway by which NO accomplishes functional diversity is the …

Nitric oxide (NO) is a key messenger in the pathogenesis of inflammation, linking innate and
adaptive immunity. By targeting signaling molecules, NO from inducible NO synthase (iNOS) …

S-nitrosylation, a prototypic redox-based posttranslational modification, is frequently
dysregulated in disease. S-nitrosoglutathione reductase (GSNOR) regulates protein S …

Significance: Glutathione (GSH) depletion is a central signaling event that regulates the
activation of cell death pathways. GSH depletion is often taken as a marker of oxidative …

Cysteine S-nitrosylation is a posttranslational modification by which nitric oxide regulates
protein function and signaling. Studies of individual proteins have elucidated specific …

Abstract S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol
dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that …

Nitric oxide is an endogenously formed gas that acts as a signaling molecule in the human
body. The signaling functions of nitric oxide are accomplished through two primer …