Asthma is a globally significant non-communicable disease with major public health
consequences for both children and adults, including high morbidity, and mortality in severe …

The normal lung function trajectory from birth to death has three phases: a growth phase
(from birth to early adulthood), a plateau phase (that lasts for a few years), and a decline …

Early-Life Origins of Chronic Obstructive Pulmonary Disease | New England Journal of Medicine
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Importance Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has
been variably associated with these disorders in offspring. Objective To determine whether …

Chronic obstructive pulmonary disease is mainly a smoking-related disorder and affects
millions of people worldwide, with a large effect on individual patients and society as a …

Atopic dermatitis often precedes the development of other atopic diseases. The atopic march
describes this temporal relationship in the natural history of atopic diseases. Although the …

Severe asthma in children is rare, accounting for only a small proportion of childhood
asthma. After addressing modifiable factors such as adherence to treatment, comorbidities …

Rationale: Although cigarette smoking is the most important cause of chronic obstructive
pulmonary disease (COPD), a substantial proportion of COPD cases cannot be explained by …

Simple spirometry and body plethysmography have been routinely used in children aged> 5
years. New techniques based on physiologic concepts that were first described almost 50 …

Asthma is a global health problem affecting around 300 million individuals of all ages, ethnic
groups and countries. It is estimated that around 250,000 people die prematurely each year …