HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Representing the major cause of morbidity and mortality for chronic lymphocytic leukemia
(CLL) patients, immunosuppression is a common feature of the disease. Effectors of the …

Aberrant induction of human leukocyte antigen-G (HLA-G) expression has been observed in
various malignancies and is strongly associated with tumor immune escape, metastasis and …

The clinical course of individual CLL patients is highly variable, with life expectancies
ranging from months to decades. Importantly, a significant subset of patients presents with …

Simple Summary Natural killer (NK) cells are immune cells with potent anti-tumor and anti-
infection activity. The potential benefit of NK cell therapy against chronic lymphocytic …

Key features of chronic lymphocytic leukemia (CLL) are defects in the immune system and
the ability of leukemic cells to evade immune defenses and induce immunosuppression …

Human leukocyte antigen G (HLA-G) is a non-classic major histocompatibility complex
(MHC) class I molecule that functions as an immune suppressive molecule. HLA-G has …

Purpose: Human leukocyte antigen-G (HLA-G) is a tumor-associated immunosuppressive
molecule involved in tumor escape mechanisms. The aim of this study is to elucidate its …

The clinical relevance of human leucocyte antigen‐G (HLA‐G) has been postulated in
malignancies. Hepatocellular carcinoma (HCC) is a major contributor to cancer incidence …

Immunotherapy with therapeutic antibodies has shown a lack of durable responses in some
patients due to resistance mechanisms. Checkpoint molecules expressed by tumor cells …