Tolerance to antifungal drug concentrations above the minimal inhibitory concentration
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …

Lysosomal membrane permeabilization (LMP) is a poorly understood regulator of
programmed cell death that involves leakage of luminal lysosomal or vacuolar hydrolases …

Scorpion toxins that block potassium channels and antimicrobial plant defensins share a
common structural CSαβ-motif. These toxins contain a toxin signature (K-C4-XN) in their …

Potassium is basic for life. All living organisms require high amounts of intracellular
potassium, which fulfils multiple functions. To reach efficient potassium homeostasis …

Finely tuned changes in cytosolic free calcium ([Ca2+] c) mediate numerous intracellular
functions resulting in the activation or inactivation of a series of target proteins …

Abstract Background Saccharomyces cerevisiae ScGdt1 and mammalian TMEM165 are two
members of the UPF0016 membrane protein family that is likely to form a new group of Ca …

Though fungi show peculiarities in the purposes and specific traits of calcium signaling
pathways, the general scheme and the most important players are well conserved if …

Glycosylation reactions in the Golgi complex and the endoplasmic reticulum utilize
nucleotide sugars as donors and produce inorganic phosphate (Pi) and acid (H+) as …

Candida glabrata is an important human fungal pathogen whose incidence continues to
rise. Because many clinical isolates are resistant to azole drugs, the drugs of choice to treat …

A high intracellular concentration of potassium (200–300 mmol/L) is essential for many yeast
cell functions, such as the regulation of cell volume and pH, maintenance of membrane …