Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring
W Li, JB Liu, LK Hou, F Yu, J Zhang, W Wu, XM Tang… - Molecular cancer, 2022 - Springer
Primary lung cancer is one of the most common malignant tumors in China. Approximately
60% of lung cancer patients have distant metastasis at the initial diagnosis, so it is …
60% of lung cancer patients have distant metastasis at the initial diagnosis, so it is …
Long-range gene regulation in hormone-dependent cancer
The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …
territories to progressively smaller substructures, such as topologically associating domains …
Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer
SG Zhao, M Bootsma, S Zhou, R Shrestha… - Nature …, 2024 - nature.com
The impact of variations in the three-dimensional structure of the genome has been
recognized, but solid cancer tissue studies are limited. Here, we performed integrated deep …
recognized, but solid cancer tissue studies are limited. Here, we performed integrated deep …
Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …
BRD9 is a critical regulator of androgen receptor signaling and prostate cancer progression
Abstract Switch/sucrose-nonfermentable (SWI/SNF) chromatin-remodeling complexes are
critical regulators of chromatin dynamics during transcription, DNA replication, and DNA …
critical regulators of chromatin dynamics during transcription, DNA replication, and DNA …
Identification of immune-related lncRNA prognostic signature and molecular subtypes for glioblastoma
W Yu, Y Ma, W Hou, F Wang, W Cheng, F Qiu… - Frontiers in …, 2021 - frontiersin.org
Background Glioblastoma multiforme (GBM) is extensively genetically and transcriptionally
heterogeneous, which poses challenges for classification and management. Long …
heterogeneous, which poses challenges for classification and management. Long …
[HTML][HTML] H3K27ac HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility
C Giambartolomei, JH Seo, T Schwarz… - The American Journal of …, 2021 - cell.com
Genome-wide association studies (GWASs) have identified more than 200 prostate cancer
(PrCa) risk regions, which provide potential insights into causal mechanisms. Multiple lines …
(PrCa) risk regions, which provide potential insights into causal mechanisms. Multiple lines …
The genomic and epigenomic landscape of double-negative metastatic prostate cancer
Systemic targeted therapy in prostate cancer is primarily focused on ablating androgen
signaling. Androgen deprivation therapy and second-generation androgen receptor (AR) …
signaling. Androgen deprivation therapy and second-generation androgen receptor (AR) …
FOXA1 regulates alternative splicing in prostate cancer
Dysregulation of alternative splicing in prostate cancer is linked to transcriptional programs
activated by AR, ERG, FOXA1, and MYC. Here, we show that FOXA1 functions as the …
activated by AR, ERG, FOXA1, and MYC. Here, we show that FOXA1 functions as the …
Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression
Abstract Distal-less homeobox-1 (DLX1) is a well-established non-invasive biomarker for
prostate cancer (PCa) diagnosis, however, its mechanistic underpinnings in disease …
prostate cancer (PCa) diagnosis, however, its mechanistic underpinnings in disease …