Protein kinases represent promising drug targets for a number of human and animal
diseases. The recent completion of the sequenced genomes of three human-infective …

The importance of protein kinases in cell signaling and cell cycle control has led to detailed
structural and functional studies in various eukaryotes, and hence to the synthesis of specific …

African trypanosomes have a tightly coordinated cell cycle to effect efficient segregation of
their single organelles, the nucleus, flagellum, and kinetoplast. To investigate cell cycle …

The LeishmaniamexicanaCRK3 gene encodes a cdc2-related protein kinase with activity
towards histone H1. Attempts to disrupt both alleles of CRK3 in the promastigote life-cycle …

The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation
of the parasite to be essential for proliferation. We present data which demonstrate that …

Polo‐like kinases (PLKs) are conserved eukaryotic cell cycle regulators, which play multiple
roles, particularly during mitosis. The function of Trypanosoma brucei PLK was investigated …

The generation of homozygous null mutants for the crk1 cdc2‐related kinase of Leishmania
mexicana was attempted using targeted gene disruption. Promastigote mutants …

CYC2 is an essential PHO80-like cyclin that forms a complex with the cdc2-related kinase
CRK3 in Trypanosoma brucei. In both procyclic and bloodstream form T. brucei, knock-down …

A cdc2-related protein kinase gene, crk3, has been isolated from the parasitic protozoan
Leishmania mexicana. Data presented here suggests that crk3 is a good candidate to be the …

Summary Two MOB1 genes, MOB1‐A and MOB1‐B, were identified in Trypanosoma brucei.
MOB1‐A of T. brucei was shown to form a complex with TbPK50, a functional homologue of …