The fundamental role of epigenetic events in cancer
Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …
Cancer epigenomics: DNA methylomes and histone-modification maps
M Esteller - Nature reviews genetics, 2007 - nature.com
An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …
Cancer-epigenetics comes of age
The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …
The power and the promise of DNA methylation markers
PW Laird - Nature Reviews Cancer, 2003 - nature.com
The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …
been a consequence of both the exciting coalescence of the chromatin and DNA …
A gene hypermethylation profile of human cancer
We are in an era where the potential exists for deriving comprehensive profiles of DNA
alterations characterizing each form of human cancer. Such profiles would provide …
alterations characterizing each form of human cancer. Such profiles would provide …
DNA methylation
R Singal, GD Ginder - Blood, The Journal of the American …, 1999 - ashpublications.org
SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC)
has generated much interest and considerable controversy during attempts to understand its …
has generated much interest and considerable controversy during attempts to understand its …
Patterns of cytosine methylation in an elite rice hybrid and its parental lines, detected by a methylation-sensitive amplification polymorphism technique
LZ Xiong, CG Xu, MA Saghai Maroof… - Molecular and General …, 1999 - Springer
DNA methylation is known to play an important role in the regulation of gene expression in
eukaryotes. In this study, we assessed the extent and pattern of cytosine methylation in the …
eukaryotes. In this study, we assessed the extent and pattern of cytosine methylation in the …
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
We used mouse embryonic stem (ES) cells with systematic gene knockouts for DNA
methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a …
methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a …
Methylation matters
JF Costello, C Plass - Journal of medical genetics, 2001 - jmg.bmj.com
DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …
the medical field that having the correct pattern of genomic methylation is essential for …
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer
H Suzuki, E Gabrielson, W Chen, R Anbazhagan… - Nature …, 2002 - nature.com
Aberrant hypermethylation of gene promoters is a major mechanism associated with
inactivation of tumor-suppressor genes in cancer. We previously showed this transcriptional …
inactivation of tumor-suppressor genes in cancer. We previously showed this transcriptional …