[HTML][HTML] Lessons learned from parsing genetic risk for schizophrenia into biological pathways
The clinically heterogeneous presentation of schizophrenia is compounded by the
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …
shifting clinical phenomena across the life span. We investigated the convergence of …
[HTML][HTML] Network-wide risk convergence in gene co-expression identifies reproducible genetic hubs of schizophrenia risk
C Borcuk, M Parihar, L Sportelli, JE Kleinman, JH Shin… - Neuron, 2024 - cell.com
The omnigenic model posits that genetic risk for traits with complex heritability involves
cumulative effects of peripheral genes on mechanistic" core genes," suggesting that in a …
cumulative effects of peripheral genes on mechanistic" core genes," suggesting that in a …
Genetic correlates as a predictor of bariatric surgery outcomes after 1 year
PK Thanos, C Hanna, A Mihalkovic, A Hoffman… - Biomedicines, 2023 - mdpi.com
This study analyzed genetic risk assessments in patients undergoing bariatric surgery to
serve as a predictive factor for weight loss parameters 1 year after the operation. Thirty (30) …
serve as a predictive factor for weight loss parameters 1 year after the operation. Thirty (30) …
[HTML][HTML] A miR-137–Related Biological Pathway of Risk for Schizophrenia Is Associated With Human Brain Emotion Processing
G Pergola, A Rampino, L Sportelli, CJ Borcuk… - Biological Psychiatry …, 2024 - Elsevier
Background miR-137 is a microRNA involved in brain development, regulating
neurogenesis and neuronal maturation. Genome-wide association studies have implicated …
neurogenesis and neuronal maturation. Genome-wide association studies have implicated …
Transcriptomics and proteomics of projection neurons in a circuit linking hippocampus with dorsolateral prefrontal cortex in human brain
RA Bharadwaj, C Borcuk, GC Kikidis, L Sportelli… - bioRxiv, 2024 - biorxiv.org
RNA-sequencing studies of brain tissue homogenates have shed light on the molecular
processes underlying schizophrenia (SCZ) but lack biological granularity at the cell type …
processes underlying schizophrenia (SCZ) but lack biological granularity at the cell type …
Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal function
Schizophrenia (SCZ) is characterized by a polygenic risk architecture implicating diverse
molecular pathways important for synaptic function. However, how polygenic risk funnels …
molecular pathways important for synaptic function. However, how polygenic risk funnels …
Diverse avenues of research support the transmethylation theory of psychosis: implications for neuroprotection
CL Miller - Exploration of Neuroprotective Therapy, 2024 - explorationpub.com
Transmethylation in the context of psychiatry has historically referred to the enzymatic
transfer of a methyl group from one biochemical to another, whose resulting function can …
transfer of a methyl group from one biochemical to another, whose resulting function can …
Close Homolog of L1 (CHL1) and its role in the dopaminergic system: biochemical and behavioral consequences of CHL1 and dopamine receptor type 2 interaction
L Fernandes - 2023 - ediss.sub.uni-hamburg.de
Dopamine is a neurotransmitter essential to coordinate biochemical and behavioral
functions in the striatum by modulating dopamine receptor signaling, including the …
functions in the striatum by modulating dopamine receptor signaling, including the …
[引用][C] Close Homolog of L1 (CHL1) and its role in the dopaminergic system: biochemical and behavioral consequences of CHL1 and dopamine receptor type 2 …
M Kneussel