Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

Recent advances in RNA delivery and target selection provide unprecedented opportunities
for cancer treatment, especially for cancers that are particularly hard to treat with existing …

The relationships between telomerase and telomeres represent attractive targets for new
anticancer agents. Here, we report that the nucleoside analogue 6-thio-2′-deoxyguanosine …

Human telomeres are tandem arrays that are predominantly composed of 5′-TTAGGG-3′
nucleotide sequences at the terminal ends of chromosomes. These sequences serve 2 …

Telomerase activity is responsible for the maintenance of chromosome end structures
(telomeres) and cancer cell immortality in most human malignancies, making telomerase an …

Only one class of targeted agents (anti-GD2 antibodies) has been incorporated into front-
line therapy for neuroblastoma since the 1980s. The Neuroblastoma New Drug …

Telomerase activation is critical in many cancers including central nervous system (CNS)
tumors. Imetelstat is an oligonucleotide that binds to the template region of the RNA …

Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and
essential to chromosome stability/integrity. In normal human cells, telomere length erodes …

The majority of high-risk neuroblastomas can be divided into three distinct molecular
subgroups defined by the presence of MYCN amplification, upstream TERT rearrangements …