The bromodomain and extraterminal (BET) protein Brd4 recruits transcriptional regulatory
complexes to acetylated chromatin. While Brd4 is considered to be a general transcriptional …

Acetylation of lysine residues is a post-translational modification with broad relevance to
cellular signalling and disease biology. Enzymes that 'write'(histone acetyltransferases …

Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression, and
virus-host pathogenesis. To gain mechanistic insight into the various biological functions of …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

Lysine acetylation is a reversible modification controlled by two groups of enzymes: lysine
acetyltransferases (KATs) and lysine deacetylases (KDACs). Acetylated lysine residues are …

Therapeutic targeting of the processes that regulate histone modification is a growing area
of scientific exploration. Although most interest has concentrated on the various families of …

The selection of chromosomal targets for retroviral integration varies markedly, tracking with
the genus of the retrovirus, suggestive of targeting by binding to cellular factors. γ-Retroviral …

Bromodomain protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain
(BET) protein family. It binds to acetylated histone tails via its tandem bromodomains BD1 …

Abstract Bromodomain‐containing 4 (BRD4), a member of Bromo and Extra‐Terminal (BET)
family, recognizes acetylated histones and is of importance in transcription, replication, and …

Retroviral integrase (IN) proteins catalyze the permanent integration of proviral genomes
into host DNA with the help of cellular cofactors. Lens epithelium-derived growth factor …