Emerging role of extracellular vesicles in intercellular communication in the brain: Implications for neurodegenerative diseases and therapeutics
S Sarkar, S Patranabis - Cell Biochemistry and Biophysics, 2024 - Springer
Extracellular vesicles (EVs) are minute lipid-bilayer sacs discharged by cells, encompassing
a diverse array of proteins, nucleic acids, and lipids. The identification of EVs as pivotal …
a diverse array of proteins, nucleic acids, and lipids. The identification of EVs as pivotal …
Translatable plasma and CSF biomarkers for use in mouse models of Huntington's disease
MK Bondulich, J Phillips, M Cañibano-Pico… - Brain …, 2024 - academic.oup.com
Huntington's disease is an inherited neurodegenerative disorder for which a wide range of
disease-modifying therapies are in development and the availability of biomarkers to …
disease-modifying therapies are in development and the availability of biomarkers to …
Facilitating Huntington's disease research: plasma neurofilament levels as a promising enrichment biomarker for HD-ISS stage 1
C Sampaio, HA Wilkinson - EBioMedicine, 2023 - thelancet.com
Parkin et al. 1 propose the use of blood neurofilament light (NfL) levels as an enrichment
biomarker for individuals with Huntington's disease (HD) who may be classified as …
biomarker for individuals with Huntington's disease (HD) who may be classified as …
Mapping neurodegeneration across the Huntington's disease spectrum: a five-year longitudinal analysis of plasma neurofilament light
Summary Background Neurofilament light (NfL) has previously been highlighted as a
potential biomarker for Huntington's Disease (HD) using cross-sectional analyses. Our study …
potential biomarker for Huntington's Disease (HD) using cross-sectional analyses. Our study …
[HTML][HTML] Serum Neurofilament Light and Clinical Biomarkers for Disease Staging in Huntington's Disease
B Heim, E Mandler, A Buchmann… - Movement …, 2024 - pmc.ncbi.nlm.nih.gov
Recently, the Huntington's Disease (HD) Integrated Staging System (HD-ISS) was
developed as a new framework to standardize clinical research for HD. 1 Nevertheless, HD …
developed as a new framework to standardize clinical research for HD. 1 Nevertheless, HD …
A 14-year longitudinal study of neurofilament light chain dynamics in premanifest and transitional Huntington's disease
ZJ Voysey, NE Owen, JA Holbrook, M Malpetti… - Journal of …, 2024 - Springer
Background Growing evidence supports the value of neurofilament light (NfL) as a
prognostic biomarker in premanifest Huntington's disease (HD). To date, however, there has …
prognostic biomarker in premanifest Huntington's disease (HD). To date, however, there has …
The Utility of Biomarkers for Huntington's Disease
EA Thomas - … for Huntington's Disease: Improving Clinical Outcomes, 2023 - Springer
Huntington's disease (HD) is a fatal, genetic, neurodegenerative disorder, characterized by
chorea, other motor instabilities, psychiatric manifestations and cognitive decline. The …
chorea, other motor instabilities, psychiatric manifestations and cognitive decline. The …