Despite advances in acute management and prevention of cerebrovascular disease, stroke
and vascular cognitive impairment together remain the world's leading cause of death and …

Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics
in response to the brain's oxygen and nutrient demands. Crucially, VSMCs may provide a …

Cumulative evidence suggests that impaired cerebrovascular reactivity (CVR), a regulatory
response critical for maintaining neuronal health, is amongst the earliest pathological …

The neurovascular unit (NVU) is a complex structure that facilitates nutrient delivery and
metabolic waste clearance, forms the blood–brain barrier (BBB), and supports fluid …

Background Cerebral small vessel disease (cSVD) is a major contributing factor to ischemic
stroke and dementia. However, the vascular pathologies of cSVD remain inconclusive. The …

Hypertension is a primary risk factor for the progression of cognitive impairment caused by
cerebral small vessel disease, the most common cerebrovascular disease. However, the …

Cerebral small vessel disease (cSVD), a common cause of stroke and dementia, is
traditionally considered the small vessel equivalent of large artery occlusion or rupture that …

Cerebral small vessel disease (CSVD) is considered as one of the main causes of cognitive
decline and dementia. However, despite extensive research, the pathogenesis of CSVD and …

INTRODUCTION White matter hyperintensity volumes (WMHVs) are disproportionally
prevalent in individuals with Alzheimer's disease (AD), potentially reflecting neurovascular …

Objective To investigate the association between cerebral small vessel disease (SVD) and
hematoma volume in primary intracerebral hemorrhage (ICH). Methods Patients from a …