The Rubinstein-Taybi syndrome (RSTS) is a rare congenital developmental disorder
characterized by a typical facial dysmorphism, distal limb abnormalities, intellectual …

BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal
survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating …

CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which
induces cell-cycle arrest and differentiation in hematologic malignancy model systems. In …

Rubinstein-Taybi syndrome (RTS) is an archetypical genetic syndrome that is characterised
by intellectual disability, well-defined facial features, distal limb anomalies and atypical …

The coactivator p300/CREB-binding protein (CBP) regulates genes by facilitating the
assembly of transcriptional machinery and by acetylating histones and other factors …

The histone acetyltransferase CREB-binding protein (CBP) and its paralogue p300 protein
are key transcriptional coactivators and attractive cancer therapeutic targets. We describe …

Multiple myeloma (MM) is a malignancy that is often driven by MYC and that is sustained by
IRF4, which are upregulated by super-enhancers. IKZF1 and IKZF3 bind to super-enhancers …

The encoding of chemical compounds with amplifiable DNA tags facilitates the discovery of
small-molecule ligands for proteins. To investigate the impact of stereo-and regiochemistry …

Adenoviral E1A binding protein 300 kDa (p300) and its closely related paralog CREB
binding protein (CBP) are promising therapeutic targets for human cancer. Here, we report …

ABSTRACT CREB‐binding protein (CBP)(CREBBP) and p300 (EP300) are multifunctional
histone acetyltransferases (HATs) with extensive homology. Germline mutations of CBP or …