Deciphering the relationship between SARS-CoV-2 and cancer

M Costanzo, MAR De Giglio, GN Roviello - International Journal of …, 2023 - mdpi.com
Some viruses are known to be associated with the onset of specific cancers. These
microorganisms, oncogenic viruses or oncoviruses, can convert normal cells into cancer …

Viral G Protein–Coupled Receptors Encoded by β-and γ-Herpesviruses

MM Rosenkilde, N Tsutsumi, JM Knerr… - Annual review of …, 2022 - annualreviews.org
Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of
their strategy to escape immune surveillance, promote virus spreading, or reprogram host …

Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins

N Tsutsumi, S Maeda, Q Qu, M Vögele, KM Jude… - Science …, 2022 - science.org
Human cytomegalovirus (HCMV) encodes G protein–coupled receptors (GPCRs) US28 and
US27, which facilitate viral pathogenesis through engagement of host G proteins. Here we …

[HTML][HTML] Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients

R Bertinat, R Villalobos-Labra, L Hofmann… - Vascular …, 2022 - Elsevier
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease
characterized by severe and persistent fatigue. Along with clinical studies showing …

Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1

N Tsutsumi, Q Qu, M Mavri, MS Baggesen, S Maeda… - Immunity, 2021 - cell.com
Epstein-Barr virus (EBV) encodes a G protein-coupled receptor (GPCR) termed BILF1 that is
essential for EBV-mediated immunosuppression and oncogenesis. BILF1 couples with …

Hijacking of GPCRs and RTKs by pathogens

MA Ayoub - Cellular Signalling, 2023 - Elsevier
Pathogens exploit multiple cellular and molecular pathways in the host organisms for their
entry, survival and dissemination. The cell surface receptors such as G protein-coupled …

The US21 viroporin of human cytomegalovirus stimulates cell migration and adhesion

A Luganini, V Serra, G Scarpellino, SM Bhat… - Mbio, 2023 - Am Soc Microbiol
The human cytomegalovirus (HCMV) US12 gene family contributes to virus-host interactions
by regulating the virus' cell tropism and its evasion of host innate immune responses. US21 …

Cytomegalovirus and Cardiovascular Disease: A Hypothetical Role for Viral G-Protein-Coupled Receptors in Hypertension

GF Bomfim, F Priviero, E Poole… - American Journal of …, 2023 - academic.oup.com
Cytomegalovirus (CMV) is a member of the β-herpesviruses and is ubiquitous, infecting 50%–
99% of the human population depending on ethnic and socioeconomic conditions. CMV …

Structural insights into KSHV-GPCR constitutive activation and CXCL1 chemokine recognition

A Liu, Y Liu, C Llinàs del Torrent Masachs… - Proceedings of the …, 2024 - pnas.org
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a viral G protein-coupled
receptor, KSHV-GPCR, that contributes to KSHV immune evasion and pathogenesis of …

Insight into structural properties of viral G protein‐coupled receptors and their role in the viral infection: IUPHAR Review 41

N Tsutsumi, DF Kildedal, OK Hansen… - British Journal of …, 2025 - Wiley Online Library
G protein‐coupled receptors (GPCRs) are pivotal in cellular signalling and drug targeting.
Herpesviruses encode GPCRs (vGPCRs) to manipulate cellular signalling, thereby …