The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with
supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane …

All ligands of the epidermal growth factor receptor (EGFR), which has important roles in
development and disease, are released from the membrane by proteases. In several …

ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored
metalloproteases that process and shed the ectodomains of membrane-anchored growth …

Aims Previous studies have demonstrated improved cardiac function following myocardial
infarction (MI) after administration of endothelial progenitor cells (EPCs) into ischaemic …

E-cadherin controls a wide array of cellular behaviors, including cell-cell adhesion,
differentiation, and tissue development. We show here that E-cadherin is cleaved …

Sprouting angiogenesis is an invasive process that involves proteolytic activities required for
the degradation of the endothelial basement membrane, cell migration with removal of …

There is an exciting increase of evidence that members of the disintegrin and
metalloprotease (ADAM) family critically regulate cell adhesion, migration, development and …

Proteolytic enzymes belonging to the A Disintegin And Metalloproteinase (ADAM) family are
able to cleave transmembrane proteins close to the cell surface, in a process referred to as …

Cadherins are critically involved in tissue development and tissue homeostasis. We
demonstrate here that neuronal cadherin (N‐cadherin) is cleaved specifically by the …