Immunofocusing is a strategy to create immunogens that redirect humoral immune
responses towards a targeted epitope and away from non-desirable epitopes …

The development of subunit vaccine platforms has been of considerable interest due to their
good safety profile and ability to be adapted to new antigens, compared to other vaccine …

A major challenge in creating universal influenza vaccines is to focus immune responses
away from the immunodominant, variable head region of hemagglutinin (HA-head) and …

Vaccination is still the most promising strategy for combating influenza virus pandemics.
However, the highly variable characteristics of influenza virus make it difficult to develop …

The continuing emergence of immune evasive SARS-CoV-2 variants and the previous
SARS-CoV-1 outbreak collectively underscore the need for broadly protective sarbecovirus …

Immunogen design approaches aim to control the specificity and quality of antibody
responses elicited by next-generation vaccines. Here, we use computational protein design …

The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is the main target of
neutralizing antibodies. Although they are infrequently elicited during infection or …

Current Influenza virus vaccines primarily induce antibody responses against variable
epitopes in hemagglutinin (HA), necessitating frequent updates. However, antibodies …

Vaccination is the most effective strategy to combat influenza. Ideally, potent and persistent
vaccine effects would be induced with a single vaccine dose. Here, we designed a virus‐like …

The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is the main target of
neutralizing antibodies. Although they are infrequently elicited during infection or …