Herpesviruses are ubiquitous, double-stranded DNA, enveloped viruses that establish
lifelong infections and cause a range of diseases. Entry into host cells requires binding of …

Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating
infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and …

Human cytomegalovirus (HCMV) enters host by glycoprotein B (gB)-mediated membrane
fusion upon receptor-binding to gH/gL-related complexes, causing devastating diseases …

Cell entry of enveloped viruses requires specialized viral proteins that mediate fusion with
the host membrane by substantial structural rearrangements from a metastable pre-to a …

Viral fusogens merge viral and cell membranes during cell penetration. Their ectodomains
drive fusion by undergoing large-scale refolding, but little is known about the functionally …

Protein-mediated membrane fusion is the dynamic process where specialized protein
machinery undergoes dramatic conformational changes that drive two membrane bilayers …

There is an unmet need for monoclonal antibodies (mAbs) for prevention or as adjunctive
treatment of herpes simplex virus (HSV) disease. Most vaccine and mAb efforts focus on …

Herpesviruses remain a burden for animal and human health, including the medically
important varicella-zoster virus (VZV). Membrane fusion mediated by conserved core …

Members of the Herpesviridae, including the medically important alphaherpesvirus varicella-
zoster virus (VZV), induce fusion of the virion envelope with cell membranes during entry …

Diseases caused by human herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) affect
millions of people worldwide and range from fatal encephalitis in neonates and herpes …