Strategies for delivering therapeutics across the blood–brain barrier

GC Terstappen, AH Meyer, RD Bell… - Nature Reviews Drug …, 2021 - nature.com
Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

The power of imaging to understand extracellular vesicle biology in vivo

FJ Verweij, L Balaj, CM Boulanger, DRF Carter… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by virtually every
cell type. EVs have diverse biological activities, ranging from roles in development and …

[HTML][HTML] Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosome-based theranostics

D Yang, W Zhang, H Zhang, F Zhang, L Chen, L Ma… - Theranostics, 2020 - ncbi.nlm.nih.gov
Exosomes are small extracellular vesicles with diameters of 30-150 nm. In both
physiological and pathological conditions, nearly all types of cells can release exosomes …

Engineered extracellular vesicles for cancer therapy

X Zhang, H Zhang, J Gu, J Zhang, H Shi… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …

Recent progress in targeted delivery vectors based on biomimetic nanoparticles

L Chen, W Hong, W Ren, T Xu, Z Qian… - Signal transduction and …, 2021 - nature.com
Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs)
since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological …

[HTML][HTML] An emerging focus on lipids in extracellular vesicles

T Skotland, K Sagini, K Sandvig, A Llorente - Advanced drug delivery …, 2020 - Elsevier
Extracellular vesicles contain a lipid bilayer membrane that protects the encapsulated
material, such as proteins, nucleic acids, lipids and metabolites, from the extracellular …

Shedding light on the cell biology of extracellular vesicles

G Van Niel, G d'Angelo, G Raposo - Nature reviews Molecular cell …, 2018 - nature.com
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures
comprising exosomes and microvesicles, which originate from the endosomal system or …

Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy

KP De Sousa, I Rossi, M Abdullahi… - Wiley …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer
nanoparticles secreted by most cells. EVs are regarded as important mediators of …

Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications

GK Patel, MA Khan, H Zubair, SK Srivastava… - Scientific reports, 2019 - nature.com
Exosomes have received significant attention for their role in pathobiological processes and
are being explored as a tool for disease diagnosis and management. Consequently, various …

New technologies for analysis of extracellular vesicles

H Shao, H Im, CM Castro, X Breakefield… - Chemical …, 2018 - ACS Publications
Extracellular vesicles (EVs) are diverse, nanoscale membrane vesicles actively released by
cells. Similar-sized vesicles can be further classified (eg, exosomes, microvesicles) based …