Sites of Cre‐recombinase activity in mouse lines targeting skeletal cells
ABSTRACT The Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss‐of‐
function and gain‐of‐function studies, as well as lineage tracing, through gene …
function and gain‐of‐function studies, as well as lineage tracing, through gene …
Spatiotemporal characterization of human early intervertebral disc formation at single‐cell resolution
T Zhou, Y Chen, Z Liao, L Zhang, D Su, Z Li… - Advanced …, 2023 - Wiley Online Library
The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae.
Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs …
Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs …
Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth
F Fu, R Bao, S Yao, C Zhou, H Luo, Z Zhang… - Scientific reports, 2021 - nature.com
Aberrant mechanical factor is one of the etiologies of the intervertebral disc (IVD)
degeneration (IVDD). However, the exact molecular mechanism of spinal mechanical …
degeneration (IVDD). However, the exact molecular mechanism of spinal mechanical …
Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities
ZY Lu, PB Chen, QY Xu, B Li, SD Jiang, LS Jiang… - JOR …, 2023 - Wiley Online Library
There have been an increasing number of patients with degenerative disc diseases due to
the aging population. In light of this, studies on the pathogenesis of intervertebral disc …
the aging population. In light of this, studies on the pathogenesis of intervertebral disc …
Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration
The circadian clock participates in maintaining homeostasis in peripheral tissues, including
intervertebral discs (IVDs). Abnormal mechanical loading is a known risk factor for …
intervertebral discs (IVDs). Abnormal mechanical loading is a known risk factor for …
[HTML][HTML] Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis
Osterix is a critical transcription factor of mesenchymal stem cell fate, where its loss or loss of
WNT signaling diverts differentiation to a chondrocytic lineage. Intervertebral disc (IVD) …
WNT signaling diverts differentiation to a chondrocytic lineage. Intervertebral disc (IVD) …
An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment
Adolescent idiopathic scoliosis (AIS) is the most common spine disorder affecting children
worldwide, yet little is known about the pathogenesis of this disorder. Here, we demonstrate …
worldwide, yet little is known about the pathogenesis of this disorder. Here, we demonstrate …
[HTML][HTML] Loss of pinch proteins causes severe degenerative disc disease-like lesions in mice
Degenerative disc disease (DDD) is one of the most common skeletal disorders affecting
aged populations. DDD is the leading cause of low back/neck pain, resulting in disability …
aged populations. DDD is the leading cause of low back/neck pain, resulting in disability …
[HTML][HTML] Leptin receptor–expressing cells represent a distinct subpopulation of notochord-derived cells and are essential for disc homoeostasis
Background/objective Intervertebral disc degeneration (IDD) remains to be an intractable
clinical challenge. Although IDD is characterised by loss of notochordal cells (NCs) and …
clinical challenge. Although IDD is characterised by loss of notochordal cells (NCs) and …
Pip5k1γ promotes anabolism of nucleus pulposus cells and intervertebral disc homeostasis by activating CaMKII‐Ampk pathway in aged mice
M Chen, F Li, M Qu, X Jin, T He, S He, S Chen… - Aging …, 2024 - Wiley Online Library
Degenerative disc disease (DDD) represents a significant global health challenge, yet its
underlying molecular mechanisms remain elusive. This study aimed to investigate the role of …
underlying molecular mechanisms remain elusive. This study aimed to investigate the role of …