Functional dental pulp regeneration: basic research and clinical translation

Z Xie, Z Shen, P Zhan, J Yang, Q Huang… - International journal of …, 2021 - mdpi.com
Pulpal and periapical diseases account for a large proportion of dental visits, the current
treatments for which are root canal therapy (RCT) and pulp revascularisation. Despite the …

[HTML][HTML] Decellularized and biological scaffolds in dental and craniofacial tissue engineering: A comprehensive overview

M Yazdanian, AH Arefi, M Alam, K Abbasi… - journal of materials …, 2021 - Elsevier
Dental problems including cavities, periodontitis, apical periodontitis, and pulpitis are among
the most cost-consuming burden for both patients and the health care system all over the …

Angiogenic hydrogels for dental pulp revascularization

Z Siddiqui, B Sarkar, KK Kim, N Kadincesme, R Paul… - Acta biomaterialia, 2021 - Elsevier
Angiogenesis is critical for tissue healing and regeneration. Promoting angiogenesis in
materials implanted within dental pulp after pulpectomy is a major clinical challenge in …

Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis: therapeutic potential for endogenous pulp regeneration

C Liang, Q Liang, X Xu, X Liu, X Gao, M Li… - International Journal of …, 2022 - nature.com
Pulp loss is accompanied by the functional impairment of defense, sensory, and nutrition
supply. The approach based on endogenous stem cells is a potential strategy for pulp …

The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients

I Ramirez, C Kirschneck, A Corrêa Silva-Sousa… - PLoS …, 2023 - journals.plos.org
The aim of this study is to evaluate if single nucleotide polymorphisms (SNPs) in WNT6 and
WNT10A are associated with the risk of dental pulp calcification in orthodontic patients. This …

Wnt3a promotes odonto/osteogenic differentiation in vitro and tertiary dentin formation in a rat model

W Sukarawan, P Rattanawarawipa… - International …, 2023 - Wiley Online Library
Aim To investigate the effect of Wnt3a on odonto/osteogenic differentiation of stem cells
isolated from human exfoliated deciduous teeth (SHEDs) and reparative dentine formation …

RvE1 promotes Axin2+ cell regeneration and reduces bacterial invasion

YC Wu, N Yu, CA Rivas, N Mehrnia… - Journal of Dental …, 2023 - journals.sagepub.com
Vital pulp therapy and root canal therapy (RCT) are the dominant treatment for irreversible
pulpitis. While the success rate of these procedures is favorable, they have some limitations …

Graphene oxide-coated porous titanium for pulp sealing: an antibacterial and dentino-inductive restorative material

N Sun, S Yin, Y Lu, W Zhang, X Jiang - Journal of Materials Chemistry …, 2020 - pubs.rsc.org
Pulp treatment techniques such as pulp capping, pulpotomy and pulp regeneration are all
based on the principle of preserving vital pulp. However, specific dental restorative materials …

Wnt3a‐Loaded Hydroxyapatite Nanowire@ Mesoporous Silica Core− Shell Nanocomposite Promotes the Regeneration of Dentin− Pulp Complex via Angiogenesis …

N Luo, YW Deng, J Wen, XC Xu… - Advanced …, 2023 - Wiley Online Library
Pulp exposure often leads to pulp necrosis, root fractures, and ultimate tooth loss. The repair
of the exposure site with pulp capping treatment is of great significance to preserving pulp …

R-spondin 2 induces odontogenic differentiation of dental pulp stem/progenitor cells via regulation of Wnt/β-catenin signaling

Y Gong, S Yuan, J Sun, Y Wang, S Liu, R Guo… - Frontiers in …, 2020 - frontiersin.org
Odontoblast cells generated from human dental pulp stem/progenitor cells (hDPSCs)
secrete reparative dentin in responds to an injury. Endogenous Wnt signaling is also …