Molecular markers have the potential to serve not only as prognostic factors but may be
targets for new therapeutic strategies and predictors of response in a range of cancers …

High‐grade PIN is the most likely precursor of prostatic adenocarcinoma, according to
virtually all available evidence to date. The clinical importance of recognizing PIN is based …

Progression of prostate cancer ultimately results in a disease that is refractory to hormone
ablation therapy but nevertheless continues to require the androgen receptor. Progression …

Purpose: The HER2 oncogene is involved in the biology of many different tumor types and
serves as a prognostic marker and a therapeutic target in breast cancer. In contrast to breast …

Tyrosine kinases play central roles in the growth and differentiation of normal and tumor
cells. In this study, we have analyzed the general tyrosine kinase expression profile of a …

Purpose: The nuclear transcription factor nuclear factor-κB (NFκB) and its inhibitor, IκB,
regulate the transcription of various genes involved in cell proliferation, adhesion, and …

BACKGROUND HER‐2/neu gene amplification, established as a prognostic factor in breast
carcinoma and other cancers, has not been correlated with outcome in prostate carcinomas …

HER2 is reported to be overexpressed in 20% of cases of non–small-cell lung cancer
(NSCLC), principally adenocarcinoma. Trastuzumab is a monoclonal antibody against …

BACKGROUND Overexpression of the HER‐2/neu oncoprotein has been reported to occur
in≤ 60% of patients with prostate carcinoma and to correlate with shortened survival …

The ERBB2 gene is overexpressed in 30% of breast cancers and this has been correlated
with poor prognosis. ERBB2 is upregulated in other cancers such as prostate, pancreas …