Structure, biochemical function, and signaling mechanism of plant NLRs

J Wang, W Song, J Chai - Molecular Plant, 2023 - cell.com
To counter pathogen invasion, plants have evolved a large number of immune receptors,
including membrane-resident pattern recognition receptors (PRRs) and intracellular …

[HTML][HTML] Calcium homeostasis and signaling in plant immunity

C Wang, S Luan - Current opinion in plant biology, 2024 - Elsevier
Abstract Calcium (Ca 2+) signaling consists of three steps:(1) initiation of a change in
cellular Ca 2+ concentration in response to a stimulus,(2) recognition of the change through …

NLR signaling in plants: from resistosomes to second messengers

S Huang, A Jia, S Ma, Y Sun, X Chang, Z Han… - Trends in biochemical …, 2023 - cell.com
Nucleotide binding and leucine-rich repeat-containing receptors (NLRs) have a critical role
in plant immunity through direct or indirect recognition of pathogen effectors. Recent studies …

Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity

X Wang, X Li, G Yu, L Zhang, C Zhang, Y Wang, F Liao… - Cell Research, 2023 - nature.com
Nicotinamide adenine dinucleotide (NAD+) is a central metabolite in cellular processes.
Depletion of NAD+ has been demonstrated to be a prevalent theme in both prokaryotic and …

Broader functions of TIR domains in Arabidopsis immunity

P Jacob, J Hige, L Song, A Bayless… - Proceedings of the …, 2023 - National Acad Sciences
TIR domains are NAD-degrading enzymes that function during immune signaling in
prokaryotes, plants, and animals. In plants, most TIR domains are incorporated into …

New biochemical principles for NLR immunity in plants

J Chai, W Song, JE Parker - Molecular Plant-Microbe …, 2023 - Am Phytopath Society
While working for the United States Department of Agriculture on the North Dakota
Agricultural College campus in Fargo, North Dakota, in the 1940s and 1950s, Harold H. Flor …

[HTML][HTML] TIR-domain enzymatic activities at the heart of plant immunity

F Locci, J Wang, JE Parker - Current Opinion in Plant Biology, 2023 - Elsevier
Abstract Toll/interleukin-1/resistance (TIR) domain proteins contribute to innate immunity in
all cellular kingdoms. TIR modules are activated by self-association and in plants, mammals …

Pangenomic analysis reveals plant NAD+ manipulation as an important virulence activity of bacterial pathogen effectors

MT Hulin, L Hill, JDG Jones… - Proceedings of the …, 2023 - National Acad Sciences
Nicotinamide adenine dinucleotide (NAD+) has emerged as a key component in prokaryotic
and eukaryotic immune systems. The recent discovery that Toll/interleukin-1 receptor (TIR) …

Taking the lead: NLR immune receptor N‐terminal domains execute plant immune responses

KS Chia, P Carella - New Phytologist, 2023 - Wiley Online Library
Nucleotide‐binding domain and leucine‐rich repeat (NLR) proteins are important
intracellular immune receptors that activate robust plant immune responses upon detecting …

[HTML][HTML] TIR-catalyzed nucleotide signaling molecules in plant defense

A Jia, S Huang, S Ma, X Chang, Z Han… - Current Opinion in Plant …, 2023 - Elsevier
Toll and interleukin-1 receptor (TIR) domain is a conserved immune module in prokaryotes
and eukaryotes. Signaling regulated by TIR-only proteins or TIR domain-containing …