Increases in intracellular free Ca 2+ play a major role in many cellular processes. The
deregulation of Ca 2+ signaling is a feature of a variety of diseases, and modulators of Ca …

Abstract The plasma membrane Ca 2+-ATPase (PMCA) is a ubiquitously expressed, ATP-
driven Ca 2+ pump that is critical for maintaining low resting cytosolic Ca 2+([Ca 2+] i) in all …

Acute pancreatitis (AP) is serious inflammatory disease of the pancreas. Accumulating
evidence links diabetes with severity of AP, suggesting that endogenous insulin may be …

Calcium ion (Ca2+) signaling is critical to many physiological processes, and its kinetics and
subcellular localization are tightly regulated in all cell types. All Ca2+ flux perturbations …

The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These
exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most …

The link between mitochondria and major depressive disorder (MDD) is increasingly
evident, underscored both by mitochondria's involvement in many mechanisms identified in …

Acute pancreatitis is currently the most common cause of hospital admission among all
nonmalignant gastrointestinal diseases. To understand the pathophysiology of the disease …

Background & Aims Pancreatitis after endoscopic retrograde cholangiopancreatography
(PEP) is thought to be provoked by pancreatic ductal hypertension, via unknown …

Key points Ca2+ signalling in different cell types in exocrine pancreatic lobules was
monitored simultaneously and signalling responses to various stimuli were directly …

Acute pancreatitis is a disease associated with inflammation and tissue damage. One
protein that protects against acute injury, including ischemic injury to both the kidney and …