The new computer-aided synthesis design tool IC SYNTH has been evaluated by comparing
its performance in predicting new ideas for route design to that of historical brainstorm …

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In this paper, a novel methodology for the synthesis of ketones via microwave irradiation
promoted direct alkylation of aldehydes by activation of the inert C (sp3)–H bond has been …

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Scoring potency is a main challenge for structure based drug design. Inductive effects of
subtle variations in the ligand are not possible to accurately predict by classical …

An efficient method of accessing new CF3-containing spiro-[indene-proline] derivatives has
been developed based on a Cp* Rh (III)-catalyzed tandem CH activation/[3+ 2]–annulation …

8.338, 413 B1 12/2012 Rueeger 8,557.826 B2 10/2013 Stamford et al. 8,563,543 B2
10/2013 Scott et al. 8,569,310 B2 10/2013 Iserloh et al. 8,729,071 B2 5, 2014 Scott et al …

The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the
B-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same …

On the basis of reported antimycobacterial property of chroman-4-one pharmacophore, a
series of chemically modified bis-spirochromanones were synthesized starting from 2 …

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