The long noncoding RNA Malat1: Its physiological and pathophysiological functions

X Zhang, MH Hamblin, KJ Yin - RNA biology, 2017 - Taylor & Francis
Recent studies suggest that in humans, DNA sequences responsible for protein coding
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …

Role of circular RNAs in brain development and CNS diseases

SL Mehta, RJ Dempsey, R Vemuganti - Progress in neurobiology, 2020 - Elsevier
In mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …

Long non-coding RNAs in ischemic stroke

MH Bao, V Szeto, BB Yang, S Zhu, HS Sun… - Cell death & …, 2018 - nature.com
Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the
cellular and molecular pathophysiological processes in stroke have been a top priority. Long …

Long noncoding RNA Malat1 regulates cerebrovascular pathologies in ischemic stroke

X Zhang, X Tang, K Liu, MH Hamblin… - Journal of …, 2017 - Soc Neuroscience
The study was designed to determine the role of long noncoding RNA (lncRNA), metastasis-
associated lung adenocarcinoma transcript 1 (Malat1), in ischemic stroke outcome. Primary …

[HTML][HTML] Down-regulation of Lncrna MALAT1 attenuates neuronal cell death through suppressing Beclin1-dependent autophagy by regulating Mir-30a in cerebral …

D Guo, J Ma, L Yan, T Li, Z Li, X Han… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: LncRNA metastasis associated lung adenocarcinoma transcript 1
(MALAT1) was reported to be highly expressed in an in vitro mimic of ischemic stroke …

Transient Focal Ischemia Significantly Alters the m6A Epitranscriptomic Tagging of RNAs in the Brain

AK Chokkalla, SL Mehta, TH Kim, B Chelluboina, J Kim… - Stroke, 2019 - Am Heart Assoc
Background and Purpose—Adenosine in many types of RNAs can be converted to m6A (N6-
methyladenosine) which is a highly dynamic epitranscriptomic modification that regulates …

A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury

K Yang, L Zeng, A Ge, S Wang, J Zeng, X Yuan… - Frontiers in …, 2022 - frontiersin.org
Cerebral infarction/ischemia-reperfusion injury is currently the disease with the highest
mortality and disability rate of cardiovascular disease. Current studies have shown that …

Exosomes from miRNA‐126‐modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke

J Wang, S Chen, W Zhang, Y Chen… - CNS Neuroscience & …, 2020 - Wiley Online Library
Aims We previously showed that the protective effects of endothelial progenitor cells (EPCs)‐
released exosomes (EPC‐EXs) on endothelium in diabetes. However, whether EPC‐EXs …

[图书][B] RNA, the epicenter of genetic information

J Mattick, P Amaral - 2023 - library.oapen.org
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Circular RNA expression profiles alter significantly in mouse brain after transient focal ischemia

SL Mehta, G Pandi, R Vemuganti - Stroke, 2017 - Am Heart Assoc
Background and Purpose—Circular RNAs (circRNAs) are a novel class of noncoding RNAs
formed from many protein-coding genes by backsplicing. Although their physiological …