Burkitt lymphoma (BL) is an aggressive form of B cell lymphoma that can affect children and
adults. The study of BL led to the identification of the first recurrent chromosomal aberration …

R-loops, nucleic acid structures consisting of an RNA–DNA hybrid and displaced single-
stranded (ss) DNA, are ubiquitous in organisms from bacteria to mammals. First described in …

In many B-cell lymphomas, chromosomal translocations are biologic and diagnostic
hallmarks of disease. An intriguing subset is formed by the so-called double-hit (DH) …

Burkitt lymphoma is a mature aggressive B-cell lymphoma derived from germinal center B
cells. Its cytogenetic hallmark is the Burkitt translocation t (8; 14)(q24; q32) and its variants …

BCL2 and MYC are oncogenes commonly deregulated in lymphomas. Concurrent BCL2
and MYC translocations (BCL2+/MYC+) were identified in 54 samples by karyotype and/or …

c-MYC is one of the most essential transcriptional factors, regulating a diverse array of
cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is …

In Burkitt lymphoma (BL), a germinal center B-cell-derived tumor, the pro-apoptotic
properties of c-MYC must be counterbalanced. Predicting that survival signals would be …

B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements, also known as
“double-hit” lymphomas (DHL), are rare neoplasms characterized by highly aggressive …

Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the
International Cancer Genome Consortium (ICGC), we performed whole genome and …

Identification of large B-cell lymphomas that are “extra-aggressive” and may require therapy
other than that used for diffuse large B-cell lymphoma, not otherwise specified (DLBCL …