Development of halogenase enzymes for use in synthesis

J Latham, E Brandenburger, SA Shepherd… - Chemical …, 2018 - ACS Publications
Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

[HTML][HTML] Flavoprotein monooxygenases: versatile biocatalysts

CE Paul, D Eggerichs, AH Westphal, D Tischler… - Biotechnology …, 2021 - Elsevier
Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts

WJH Van Berkel, NM Kamerbeek, MW Fraaije - Journal of biotechnology, 2006 - Elsevier
During the last decades a large number of flavin-dependent monooxygenases have been
isolated and studied. This has revealed that flavoprotein monooxygenases are able to …

The production of fine chemicals by biotransformations

AJJ Straathof, S Panke, A Schmid - Current opinion in biotechnology, 2002 - Elsevier
Today, biocatalysis is a standard technology for the production of chemicals. An analysis of
134 industrial biotransformations reveals that hydrolases (44%) and redox biocatalysts …

Enzyme-mediated oxidations for the chemist

F Hollmann, IWCE Arends, K Buehler, A Schallmey… - Green …, 2011 - pubs.rsc.org
Biocatalysis is an enabling technology adding to organic oxidation chemistry. Especially the
high selectivity of enzymatic oxidation coevally operating under mild conditions and not …

Industrial biotechnology—the future of green chemistry?

S Wenda, S Illner, A Mell, U Kragl - Green Chemistry, 2011 - pubs.rsc.org
Biocatalysis fulfils many key criteria of green chemistry, but this raises the question: how
efficient are such production methods and how important is biotechnology for greener …

Monooxygenases as biocatalysts: classification, mechanistic aspects and biotechnological applications

DET Pazmiño, M Winkler, A Glieder, MW Fraaije - Journal of biotechnology, 2010 - Elsevier
Monooxygenases are enzymes that catalyze the insertion of a single oxygen atom from O2
into an organic substrate. In order to carry out this type of reaction, these enzymes need to …

Whole-cell biocatalysis for selective and productive C–O functional group introduction and modification

M Schrewe, MK Julsing, B Bühler… - Chemical Society Reviews, 2013 - pubs.rsc.org
During the last decades, biocatalysis became of increasing importance for chemical and
pharmaceutical industries. Regarding regio-and stereospecificity, enzymes have shown to …

Solvent-tolerant bacteria for biotransformations in two-phase fermentation systems

HJ Heipieper, G Neumann, S Cornelissen… - Applied microbiology …, 2007 - Springer
Product removal from aqueous media poses a challenge in biotechnological whole-cell
biotransformation processes in which substrates and/or products may have toxic effects. The …

[PDF][PDF] How Green is Biocatalysis? To Calculate is To Know.

Y Ni, D Holtmann, F Hollmann - ChemCatChem, 2014 - researchgate.net
Green chemistry aims to minimize the environmental hazards of chemical processes and
their products. Ever since its introduction by Anastas,[1] this principle has inspired …