Multivalency as a chemical organization and action principle

C Fasting, CA Schalley, M Weber… - Angewandte Chemie …, 2012 - Wiley Online Library
Multivalent interactions can be applied universally for a targeted strengthening of an
interaction between different interfaces or molecules. The binding partners form cooperative …

Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors

M Mammen, SK Choi… - Angewandte Chemie …, 1998 - Wiley Online Library
Found throughout biology, polyvalent interactions are characterized by the simultaneous
binding of multiple ligands on one biological entity to multiple receptors on another (top part …

Antiviral polymers: past approaches and future possibilities

RH Bianculli, JD Mase, MD Schulz - Macromolecules, 2020 - ACS Publications
Treating a viral disease is no simple feat. Drug resistance, latent reservoirs in the body,
emerging novel viruses, and a frequent lack of specific treatments all complicate antiviral …

Glycopolymer nanobiotechnology

Y Miura, Y Hoshino, H Seto - Chemical reviews, 2016 - ACS Publications
Molecular recognition plays an important role in living systems. 1, 2 Representative
molecular recognitions in living organisms are saccharide− protein, protein− protein, and …

Polymer therapeutics: concepts and applications

R Haag, F Kratz - Angewandte Chemie International Edition, 2006 - Wiley Online Library
Polymer therapeutics encompass polymer–protein conjugates, drug–polymer conjugates,
and supramolecular drug‐delivery systems. Numerous polymer–protein conjugates with …

Binding revisited—avidity in cellular function and signaling

S Erlendsson, K Teilum - Frontiers in molecular biosciences, 2021 - frontiersin.org
When characterizing biomolecular interactions, avidity, is an umbrella term used to describe
the accumulated strength of multiple specific and unspecific interactions between two or …

Thermodynamic studies of lectin− carbohydrate interactions by isothermal titration calorimetry

TK Dam, CF Brewer - Chemical reviews, 2002 - ACS Publications
Thermodynamic Studies of Lectin−Carbohydrate Interactions by Isothermal Titration
Calorimetry | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log …

Polyvalente Wechselwirkungen in biologischen Systemen: Auswirkungen auf das Design und die Verwendung multivalenter Liganden und Inhibitoren

M Mammen, SK Choi, GM Whitesides - Angewandte Chemie, 1998 - Wiley Online Library
Überall in der Biologie kommen polyvalente Wechselwirkungen vor. Sie zeichnen sich
durch die gleichzeitige Bindung mehrerer Liganden einer biologischen Einheit an mehrere …

Nanostructured glycan architecture is important in the inhibition of influenza A virus infection

SJ Kwon, DH Na, JH Kwak, M Douaisi, F Zhang… - Nature …, 2017 - nature.com
Rapid change and zoonotic transmission to humans have enhanced the virulence of the
influenza A virus (IAV). Neutralizing antibodies fail to provide lasting protection from …

Strength in numbers: non-natural polyvalent carbohydrate derivatives

LL Kiessling, NL Pohl - Chemistry & biology, 1996 - cell.com
Many processes mediated by protein-carbohydrate interactions involve multivalent low-
affinity binding, which is inherently difficult to study. New structural templates for the …