Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted
processes within the highly complex and dynamic ecosystem of the gastrointestinal tract …

The pathogenesis of gastric cancer is complex and related to multiple factors. Dysregulation
of intracellular signaling pathways represents a common pathogenic mechanism and may …

Neurotrophins are a family of growth factors that regulate neural survival, development,
function and plasticity in the central and the peripheral nervous system. There are four …

Purpose Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophic
factors that can potentially increase cancer cell growth, survival, proliferation, anoikis, and …

Cancers of the digestive system, including esophageal, gastric, pancreatic, hepatic, and
colorectal cancers, have a high incidence and mortality worldwide. Efficient therapies have …

Purpose Colorectal cancer (CRC) is a main cause of morbidity and mortality in the world.
Chemoradioresistance is a major problem in CRC treatment. Identification of novel …

Neuroblastoma (NB) is a common childhood malignant tumor of the neural crest-derived
sympathetic nervous system. In NB the frequent loss of heterozygosity (LOH) on …

Shikonin, a natural naphthoquinone isolated from a traditional Chinese medicinal herb, has
been reported to promote tumor cell death. However, there are few reports concerning its …

p75NTR, a member of TNF receptor family, is the low affinity receptor common to several
mature neurotrophins and the high affinity receptor for pro-neurotrophins. Brain-Derived …

Summary c-Kit is a classic proto-oncogene either mutated or upregulated in cancer cells,
and this leads to its constitutive kinase activation and, thus, to uncontrolled proliferation …