IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …

Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a
mother can accept a genetically distinct fetus without immunological aggressive behavior …

At first sight the bleeding disorder hemophilia A seems to have little in common with immune
disorders, but immunology research intersects with other disciplines including hematology …

Development of neutralizing antibodies against biotherapeutic agents administered to
prevent or treat various clinical conditions is a longstanding and growing problem faced by …

Abstract The European Hematology Association (EHA) Roadmap for European Hematology
Research highlights major achievements in diagnosis and treatment of blood disorders and …

As an essential modulator of IgG disposition, the neonatal Fc receptor (FcRn) governs the
pharmacokinetics and functions many therapeutic modalities. In this review, we thoroughly …

Disorders of coagulation, resulting in serious risks for bleeding, may be caused by
autoantibody formation or by mutations in genes encoding coagulation factors. In the latter …

Anti-factor VIII (FVIII) antibodies is a major complication of FVIII replacement therapy for
hemophilia A. We investigated the immune response to recombinant human factor VIII Fc …

Introduction Immune tolerance induction (ITI) is the gold standard for eradication of factor VIII
inhibitors in severe haemophilia A; however, it usually requires treatment for extended …