Boosting endogenous dopamine production: a novel therapeutic approach for Parkinson's disease
Innovative therapeutic strategies are urgently needed for Parkinson's disease due to limited
efficacy of current treatments and a weak therapeutic pipeline. In this forum article, we …
efficacy of current treatments and a weak therapeutic pipeline. In this forum article, we …
[HTML][HTML] Maternal immune activation and estrogen receptor modulation induce sex-specific dopamine-related behavioural and molecular alterations in adult rat …
SR Debs, I Conn, B Navaneethan, AG Penklis… - Brain, Behavior, and …, 2024 - Elsevier
Dopamine dysregulation contributes to psychosis and cognitive deficits in schizophrenia that
can be modelled in rodents by inducing maternal immune activation (MIA). The selective …
can be modelled in rodents by inducing maternal immune activation (MIA). The selective …
Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits
Background Parkinson's disease is characterized by a progressive loss of dopaminergic
neurons in the nigrostriatal pathway, leading to dopamine deficiency and motor …
neurons in the nigrostriatal pathway, leading to dopamine deficiency and motor …
Age-related decline of PKA-RIIβ level in SNc dopaminergic neurons underlies PD pathogenesis
Y Zhao, B Wang, M Zhao, J Liu, Y Hou, S Wei, C Xiong… - bioRxiv, 2024 - biorxiv.org
The cyclic-AMP dependent protein kinase A (Protein kinase A, PKA) regulates dopaminergic
function in the substantia nigra pars compacta (SNc). However, whether PKA is involved in …
function in the substantia nigra pars compacta (SNc). However, whether PKA is involved in …