Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

We discuss the upstream regulators of myogenesis that lead to the activation of myogenic
determination genes and subsequent differentiation, focusing on the mouse model. Key …

MyoD, Myf5, myogenin, and MRF4 (also known as Myf6 or herculin) are myogenic
regulatory factors (MRFs). MRFs are regarded as master transcription factors that are …

Macrophage gene expression determines phagocyte responses and effector functions.
Macrophage plasticity has been mainly addressed in in vitro models that do not account for …

Skeletal muscle stem cells, or" satellite cells"(SCs), are required for the regeneration of
damaged muscle tissue. Although SCs self-renew during regeneration, the mechanisms that …

The muscle satellite cell is essential for skeletal muscle regeneration. It is located on the
muscle fibre, under the basal lamina as a quiescent cell, which becomes activated after …

Muscle cell fusion is a multistep process involving cell migration, adhesion, membrane
remodeling and actin-nucleation pathways to generate multinucleated myotubes. However …

In vertebrates, the skeletal muscles of the body and their associated stem cells originate
from muscle progenitor cells, during development. The specification of the muscles of the …

Skeletal muscle regeneration relies on a pool of resident muscle stem cells called satellite
cells (MuSCs). Following injury-induced destruction of the myofibers, quiescent MuSCs are …

Adult pluripotent stem cell (aPSC) populations underlie whole-body regeneration in many
distantly-related animal lineages, but how the underlying cellular and molecular …