The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …

Most chronic diseases—such as cancer, cardiovascular disease (CVD), Alzheimer disease,
Parkinson disease, arthritis, diabetes and obesity—are becoming leading causes of …

S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified
from the National Cancer Institute chemical libraries by using structure-based virtual …

The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway is associated with the regulation of essential cellular mechanisms, such as …

Constitutive activation of signal transducer and activator of transcription (STAT) proteins has
been detected in a wide variety of human primary tumor specimens and tumor cell lines …

Abstract Signal Transducers and Activators of Transcription (STATs) are a family of
cytoplasmic proteins with roles as signal messengers and transcription factors that …

Signal transducers and activators of transcription (STAT) proteins comprise a family of
transcription factors latent in the cytoplasm that participate in normal cellular events, such as …

Numerous reports suggest that IL-6 promotes survival and proliferation of multiple myeloma
(MM) cells through the phosphorylation of a cell signaling protein, STAT3. Thus, agents that …

The contribution of prolactin (PRL) to the pathogenesis and progression of human breast
cancer at the cellular, transgenic, and epidemiological levels is increasingly appreciated …

Abnormal differentiation of myeloid cells is one of the hallmarks of cancer. However, the
molecular mechanisms of this process remain elusive. In this study, we investigated the …