Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …

The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain
transmission both in peripheral and central nervous system (CNS). Despite evidence of a …

Introduction We investigated plasma proteomic markers of astrocytopathy, brain
degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset …

J. Neurochem.(2010) 115, 814–828. Abstract Vascular cognitive impairment (VCI)
encompasses vascular dementia and is the second most common cause of dementing …

Background and Purpose—Brain-derived neurotrophic factor (BDNF), a major neurotrophin
and vascular endothelial growth factor (VEGF) have a documented role in neurogenesis …

Neurotrophins and neuropeptides are the essential regulators of peripheral nociceptive
nerves that help to induce, sensitize, and maintain pain. Neuropeptide has a neuroprotective …

Stroke remains the leading cause of long-term disability with no pharmacological
approaches available to limit the degree of damage or aid in recovery. Considerable effort …

Depression is a major contributor to the global burden of disease and disability, yet it is
poorly understood. Here we review data supporting a novel theoretical model for the biology …

Although brain-derived neurotrophic factor (BDNF) plays a central role in recovery after
cerebral ischemia, little is known about cells involved in BDNF production after stroke. The …

Cortical capillaries are prone to obstruction, which over time, could have a major impact on
brain angioarchitecture and function. The mechanisms that govern the removal of these …