The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …

Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …

Social isolation poses a severe mental and physiological burden on humans. Most animal
models that investigate this effect are based on prolonged isolation, which does not mimic …

Nucleosomes composed of histone octamer and DNA are the basic structural unit in the
eukaryote chromosome. Under the stimulation of various factors, histones will undergo …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
significant and complex genetic etiology. GWAS studies have identified genetic variants …

Background Osteosarcoma (OS) is the most common malignant tumor of bone, and the
clinical efficacy of current treatments and associated survival rates need to be further …

Colorectal cancer (CRC) stem cells are resistant to cancer therapy and are therefore
responsible for tumour progression after conventional therapy fails. However, the molecular …

The cell division cycle-associated protein (CDCA) family is important in regulating cell
division. High CDCA expression is significantly linked to tumor development. This review …

The adult brain is a complex structure with distinct functional sub-regions, which are
generated from an initial pool of neural epithelial cells within the embryo. This transition …

The neocortex is considered the seat of higher cognitive function in humans. It develops
from a sheet of neural progenitor cells, most of which eventually give rise to neurons. This …