The pyrazole nucleus is an aromatic azole heterocycle with two adjacent nitrogen atoms.
Pyrazole derivatives have exhibited a broad spectrum of biological activities, and approved …

Pyrazole is a five membered and two-nitrogen containing heterocyclic ring. These structures
have been investigated in the development of novel compounds with hypoglycemic …

Non-edible feedstocks such as animal fat wastes (AFWs) have recently increased in
popularity as alternatives to vegetable oils in the production of biodiesel. They are low cost …

Pyrazole, an important pharmacophore and a privileged scaffold of immense significance, is
a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti …

Highlights•We synthesized new diflunisal hydrazide–hydrazones.•We investigated their
activity against hepatitis C virus (HCV).•Some compounds exhibited strong inhibition against …

Tolmetin hydrazide and a novel series of tolmetin hydrazide–hydrazones 4a–l were
synthesized in this study. The structures of the new compounds were determined by spectral …

Cyclooxygenase enzymes play a vital role in inflammatory pathways in the human body.
Apart from their relation with inflammation, the additional involvement of COX-2 enzyme with …

Recently, the development of nanocatalysts based on naturally occurring polysaccharides
has received a lot of attention. Chitosan (CS), as a biodegradable and biocompatible …

Protein kinases orchestrate diverse cellular functions; however, their dysregulation is linked
to metabolic dysfunctions, associated with many diseases, including cancer. Mitogen …

Twenty new 2-(1 H-pyrazol-1-yl)-1, 3, 4-thiadiazole analogs were synthetized to develop
P2X7 receptor (P2X7R) inhibitors. P2X7R inhibition in vitro was evaluated in mouse …