Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require
painstakingly long-term treatment with an immense financial burden to healthcare systems …

Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are
still poorly understood, and current therapies are limited. Poor wound healing after trauma …

Background: Given the demonstrated utility of Third Generation Sequencing [Pacific
Biosciences (PacBio) and Oxford Nanopore Technologies (ONT)] long reads in many …

Human apolipoprotein E (ApoE) apolipoprotein is primarily expressed in three isoforms
(ApoE2, ApoE3, and ApoE4) that differ only by two residues. ApoE4 constitutes the most …

Gene therapy has historically been defined as the addition of new genes to human cells.
However, the recent advent of genome-editing technologies has enabled a new paradigm in …

It is extremely rare for a single experiment to be so impactful and timely that it shapes and
forecasts the experiments of the next decade. Here, we review how two such experiments …

Approaches to differentiating pluripotent stem cells (PSCs) into neurons currently face two
major challenges—(i) generated cells are immature, with limited functional properties; and …

The skin is the largest organ of the body and has an array of functions. Skin compartments,
epidermis, and hair follicles house stem cells that are indispensable for skin homeostasis …

Stem-Cell Research and Clinical Application Stem cells have been the focus of hope, hype,
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …