Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

The eight enzymes responsible for the biosynthesis of the three branched-chain amino acids
(l-isoleucine, l-leucine, and l-valine) were identified decades ago using classical genetic …

A hallmark of tuberculosis is the ability of the causative agent, Mycobacterium tuberculosis,
to persist for decades despite a vigorous host immune response. Previously, we identified a …

An increasing number of microbial genomes have been completely sequenced, and the
identified genes are categorized based on their homology to genes of known function …

Tuberculosis is the leading cause of death in the world resulting from a single bacterial
infection. Despite its enormous burden on world health, little is known about the molecular …

Tuberculosis remains the greatest cause of death worldwide due to a single pathogen. In
order to identify the genes required for the pathogenicity of Mycobacterium tuberculosis, a …

“If we ask further what significance belongs to the results gained in this study of tuberculosis
it must be considered a gain for science that it has been possible for the first time to establish …

Although the study of microbe-host interactions has been traditionally dominated by an
interest in pathogenic associations, there is an increasing awareness of the importance of …

mariner family transposons are widespread among eukaryotic organisms. These
transposons are apparently horizontally transmitted among diverse eukaryotes and can also …

A better understanding of Mycobacterium tuberculosis virulence mechanisms is highly
dependent on the design of efficient mutagenesis systems. A system enabling the positive …