The rise of antibiotic resistance is a threat to global health. Rapid and comprehensive
analysis of infectious strains is critical to reducing the global use of antibiotics, as informed …

Antibiotic resistance is an enormous problem that is accountable for over a million deaths
annually, with numbers expected to significantly increase over the coming decades …

Persister and viable but non-culturable (VBNC) cells are two clonal subpopulations that can
survive multidrug exposure via a plethora of putative molecular mechanisms. Here, we …

Phenotypic variations between individual microbial cells play a key role in the resistance of
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …

The interactions between bacteria and bacteriophage have important roles in the global
ecosystem; in turn changes in environmental parameters affect the interactions between …

One of the deepest branches in the tree of life separates the Archaea from the Bacteria.
These prokaryotic groups have distinct cellular systems including fundamentally different …

Antimicrobial resistance is an urgent threat to human health, and new antibacterial drugs are
desperately needed, as are research tools to aid in their discovery and development …

The interaction between a cell and its environment shapes fundamental intracellular
processes such as cellular metabolism. In most cases growth rate is treated as a proximal …

Infections by Gram-negative pathogens are usually difficult to manage due to the drug export
by efflux pumps. With the evolution and horizontal transfer of efflux pumps, there is an urgent …

The Ff family of filamentous bacteriophages infect gram-negative bacteria, but do not cause
lysis of their host cell. Instead, new virions are extruded via the phage-encoded pIV protein …