Hydroxyl radical is a significant player in oxidative DNA damage in vivo

B Halliwell, A Adhikary, M Dingfelder… - Chemical Society …, 2021 - pubs.rsc.org
Recent publications have suggested that oxidative DNA damage mediated by hydroxyl
radical (˙ OH) is unimportant in vivo, and that carbonate anion radical (CO3˙−) plays the key …

Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis

RJ Reiter, SA Rosales-Corral, DX Tan… - International journal of …, 2017 - mdpi.com
There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

Formation and processing of DNA damage substrates for the hNEIL enzymes

AM Fleming, CJ Burrows - Free Radical Biology and Medicine, 2017 - Elsevier
Reactive oxygen species (ROS) are harnessed by the cell for signaling at the same time as
being detrimental to cellular components such as DNA. The genome and transcriptome …

Unraveling the Mechanism of the Oxidative C–C Bond Coupling Reaction Catalyzed by Deoxypodophyllotoxin Synthase

Y Su, W Lai - Inorganic Chemistry, 2024 - ACS Publications
Deoxypodophyllotoxin synthase (DPS), a nonheme Fe (II)/2-oxoglutarate (2OG)-dependent
oxygenase, is a key enzyme that is involved in the construction of the fused-ring system in …

Coping with inevitable accidents in metabolism

A Danchin - Microbial Biotechnology, 2017 - Wiley Online Library
Genomic studies focus on key metabolites and pathways that, despite their obvious
anthropocentric design, keep being 'predicted', while this is only finding again what is …

DNA damage by the sulfate radical anion: hydrogen abstraction from the sugar moiety versus one-electron oxidation of guanine

M Roginskaya, R Mohseni… - Free Radical …, 2016 - Taylor & Francis
The products of oxidative damage to double-stranded (ds) DNA initiated by photolytically
generated sulfate radical anions SO4•− were analyzed using reverse-phase (RP) high …

How cancer can be caused by microwave frequency electromagnetic field (EMF) exposures: EMF activation of voltage-gated calcium channels (VGCCs) can cause …

ML Pall - Mobile Communications and Public Health, 2018 - taylorfrancis.com
Thirty reviews each argue that microwave frequency electromagnetic fields (EMFs) can and
do cause cancer. These conclusions should be definitive and are further buttressed by the …

The Influence of Spirodi (Iminohydantoin) on Charge Transfer through ds-DNA Containing 8-OXO-dG: A Theoretical Approach

BT Karwowski - International Journal of Molecular Sciences, 2023 - mdpi.com
Genetic information stored in a DNA base sequence is continuously exposed to harmful
factors. It has been determined that 9× 104 different DNA damage events occur in a single …

One-electron oxidation of guanine derivatives: Detection of 2, 5-diaminoimidazolone and novel guanine-guanine cross-links as major end products

Y Razskazovskiy, EB Campbell, ZD Cutright… - Radiation Physics and …, 2022 - Elsevier
Oxidation of guanine derivatives initiated by electron transfer is different from the process
initiated by hydroxyl radical attack in many aspects. The initially generated radical cation …

Reaction of CO3−• with trinitrotoluene (TNT) in CO2 plasma: experimental and theoretical study on the formation of [TNT+ O]−• and its fragmentation pathways

S Ninomiya, K Hiraoka, N Tsuchida… - International Journal of …, 2021 - Elsevier
It has previously been demonstrated that 2, 4, 6-trinitrotoluene (TNT) exhibits characteristic
reactivity with negative reactant ions generated in air or O 2 during atmospheric-pressure …